• A large crowd of Start6 students and students from across MIT came to hear Drew Houston discuss startup culture and know-how on Jan. 27.

    Photo: Rahul Rithe

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  • Institute professor Robert Langer discussed the formula he has used to start 26 companies.

    Photo: Rahul Rithe

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Drew Houston and Bob Langer encourage Start6 students at completion of IAP workshop


Start6, the new Department of Electrical Engineering and Computer Science (EECS) IAP workshop for immersion in innovation and entrepreneurship, wrapped up its third week with sendoffs from two icons in the world of startups: Drew Houston ’05, cofounder and CEO of Dropbox, and Institute Professor Bob Langer.

Houston joined Anantha Chandrakasan, EECS department head and creator of Start6, for a fireside chat on Jan. 27. A crowd of interested students from across campus came to hear Houston describe his experiences and offer advice on taking the plunge to launch a startup.

More software-driven startups mean more computer-science-educated and technically savvy CEOs

Pointing out how enrollment in EECS and particularly in computer science (CS) is up almost 30 percent, Chandrakasan queried Houston about the place of CS in the overall MIT curriculum. “Should computing be a general Institute requirement, like chemistry or physics, for example?” Chandrakasan asked.

Houston not only agreed that CS should be an Institute requirement, but made the case for this change. He pointed out that over the last 15 years, the Internet has completely changed how people find information and how they act and use commerce — giving as an example the widespread use of credit cards online. “Now all kinds of major industries, including education and agriculture, are being turned upside-down by software, which is rocking all industry,” Houston told the large crowd gathered in 34-101. “So absolutely, people are massively underestimating the shift. It’s now not only possible but ordinary that a couple of kids in a dorm room can build something that reaches millions of people, completely changing the way [people] do something.”

As a student at MIT, Houston said, he not only loved 6.046, Intro to Algorithms, but also discovered, while taking several management classes, that methodologies in the business world, including negotiation, were not magic: They followed an understandable framework. He suggested that picking up the business side on the fly was not out of reach for any MIT engineering student. “VCs are a lot happier if you’re wearing a brass rat from Course 6,” he noted, “than an MBA from Harvard.”

Chandrakasan asked Houston about the November 2013 Forbes article on Stanford University versus MIT startups — a piece that suggested that marketing-based startups out of Stanford trump technology-driven startups out of MIT.

Houston repeated that as more and more industries are software-driven, technology will be more and more important. “Although Stanford students are surrounded with startups everywhere in the Bay Area,” Houston said, “think about Zuckerberg and Gates … engineers first and then picked up the business side. It’s not some other class of people that can only figure this [marketing and management] out.”

Preparing MIT to lead the new wave of entrepreneurs

Houston also suggested that as MIT seeks to foster entrepreneurship, more students should be encouraged to take internships of up to six months with top-tier, venture-backed startups. He was personally involved in five other startups before Dropbox.

Houston was also involved as an MIT undergraduate in leadership roles such as running fraternity rush and becoming active in an entrepreneurship club. He trained himself on management principles by poring over management textbooks he bought online.

“What got you up to speed to take on founding Dropbox?” one student asked.

Houston responded that the process took lots of “baby steps,” from his first startup internship as a senior in high school to deciding to build Dropbox with Course 6 classmate and then junior, Arash Ferdowsi, to managing a company of over 500 employees. At the time he conceived of Dropbox — after forgetting his memory stick as he left Boston for New York City in late 2006, after he had graduated — Houston recognized the beauty of MIT’s Athena workstations. A workstation had always been available when he was a student. His and Ferdowsi’s goal as they developed the code that became Dropbox was to create an Athena station for the world. “It felt delusional … to have this goal,” Houston said. “But that was when there were just two of us.”

Product-based versus software-based startups: Bob Langer’s formula

David H. Koch Institute Professor Robert S. Langer, the most cited engineer in history and founder of 26 companies, gave the final Start6 sendoff on Jan. 28. He shared his formula with a receptive group.

Langer recommended starting with platform-building technologies for long-term successful manufacturing of products that are covered by a broad blocking patent and established by publication in a top journal. He encouraged what he called the “champion effect.” “You want people who will walk through walls to make things work to be at the company,” he said. “You care a lot more for [their] passion than experience.” He cited the example of Steve Jobs’s starting Apple, the company’s subsequent decline when Jobs was forced to leave, and its historic rise to the top upon his return.

From the lab to creating companies — a less common concept in the 1970s

Langer told the stories of six companies that he founded with his students, starting in the late 1970s. He noted that in five of the six, the idea of starting a company followed the publication and broad patent of the original discovery. And although MIT was not actively encouraging startups in those days, he said, his experiences were all successful: Not one of the companies has gone under.

As a postdoc in the 1970s under Dr. Judah Folkman at Boston Children’s Hospital, Langer, after 200 unsuccessful trials, found a way to deliver large molecules in unaltered state for slow-release therapeutic treatments. He published the work in Nature. Although Children’s Hospital had never filed for a patent and the U.S. Patent Office turned down his requests for five years, Langer was able to gather literature citations pointing to how surprising his results were, and the scientists who wrote them signed affidavits to that effect. The patent examiner was convinced by these statements, and a very broad patent was granted.

Several large companies licensed this patent but didn’t work very hard to develop them, Langer said. So with a group of former students, he started a company, which merged with the nascent company on the floor below. Today, Alkermes, a $7 billion company with 1,200 employees, produces 25 products that treat schizophrenia, diabetes, and other major human disorders.

After describing five other companies and answering questions, Langer advised that the biggest reason for success or failure is the CEO. He also urged younger inventors to do due diligence to determine how to deal with venture capitalists and investors. “The pie is only so big,” he said. “Dig deep in your heart about what you want to do.”

In answer to a question about Houston’s lack of emphasis on patents, Langer agreed with Houston’s advice, noting the importance of patents in the life sciences compared with the information and computer sciences, where marketing takes a bigger role. From their own perspectives, Langer and Houston each encouraged the Start6 students to launch startups. “Do it now,” Houston said.

Start6 concluded its final day (of 12) with the last of the individual project presentations — all potential startups that will continue to benefit from further mentorship and development. Start6 students were also invited to sign up for a spring break trip to the Bay Area to visit with several VCs and startups.


Topics: Special events and guest speakers, Innovation and Entrepreneurship (I&E), Startups

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